Polyazapolycyclics by condensation of aldehydes with amines. 2. Formation of 2, 4, 6, 8, 10, 12-hexabenzyl-2, 4, 6, 8, 10, 12-hexaazatetracyclo [5.5. 0.05. 9.03, 11] …

AT Nielsen, RA Nissan, DJ Vanderah…

Index: Nielsen, Arnold T.; Nissan, Robin A.; Vanderah, David J.; Coon, Clifford L.; Gilardi, Richard D.; et al. Journal of Organic Chemistry, 1990 ,  vol. 55,  # 5  p. 1459 - 1466

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Citation Number: 143

Abstract

Hexabenzylhexaazaisowurtzitane (2a) is prepared in a very facile manner by condensation of nearly stoichiometric quantities of benzylamine with 40% aqueous glyoxal in aqueous acetonitrile solvent (15% total water) at 25" C. An acid catalyst (formic acid, 0.1 molar% of the amine) is required. The reaction is rapid and nearly complete within a few hours. Crystalline 2a separates from the reactiom mixture and is recovered by filtration and ...