Efficient synthesis of natural polyphenolic stilbenes: resveratrol, piceatannol and oxyresveratrol
…, YC Cai, Y Chen, W Wei, XK Liu, ZL Lv, Y Zou
Index: Sun, Hong-Yi; Xiao, Chun-Fen; Cai, Yu-Chen; Chen, Yu; Wei, Wen; Liu, Xian-Ke; Lv, Ze-Liang; Zou, Yong Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 11 p. 1492 - 1496
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Citation Number: 31
Abstract
The practical synthesis of important natural polyphenolic stilbenes, including resveratrol, piceatannol and oxyresveratrol, through Perkin methodology is described. Starting from 3, 5- dihydoxyacetophenone (1), the common intermediate 3, 5-dimethoxyphenylacetic acid (3) can be obtained via methylation and Willgerodt–Kindler reaction. Perkin condensations between (3) and substituted phenylaldehydes 4 furnished E-2, 3-diarylacrylic acids 5, ...
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