Tetrahedron letters

Total synthesis of the unusual cyclosporine amino acid MeBMT

RD Tung, DH Rich

Index: Tung, Roger D.; Rich, Daniel H. Tetrahedron Letters, 1987 ,  vol. 28,  # 11  p. 1139 - 1142

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Citation Number: 44

Abstract

Sharpless epoxidation of the readily available dienol 2, followed by regiospecific Summary: opening with Me CuLVBF3eEt20 yields, after protecting group manipulation, the monoprotected diol l& Swern oxidation gives the cyclic carbaminol J&a which is easily manipulated to a-cyano bxazolidinone x and thus, by literature methods, to the title compound. Using this procedure, good overall yield and high enantiomeric purity are ...