The Journal of Organic Chemistry

Stereospecific (methylenecyclopropyl) acetyl-CoA inactivation of general acyl-CoA dehydrogenase from pig kidney

JE Baldwin, DW Parker

Index: Baldwin, John E.; Parker, David W. Journal of Organic Chemistry, 1987 ,  vol. 52,  # 8  p. 1475 - 1477

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Citation Number: 34

Abstract

An efficient synthesis of racemic methylenecyclopropaneacetic acid has been developed. A mixture of the corresponding diastereomeric coenzyme A esters, one of which is the metabolite of the nonprotein amino acid hypoglycin from Blighia sapida directly responsible for its hypoglycemic potency, reacts stereospecifically with general acyl-CoA dehydrogenase from pig kidney to irreversibly inactivate the enzyme.