Tetrahedron letters

Dynamic kinetic resolution of epichlorohydrin via enantioselective catalytic ring opening with TMSN 3. Practical synthesis of aryl oxazolidinone antibacterial agents

SE Schaus, EN Jacobsen

Index: Schaus, Scott E.; Jacobsen, Eric N. Tetrahedron Letters, 1996 , vol. 37, # 44 p. 7937 - 7940

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Citation Number: 96

Abstract

The dynamic kinetic resolution of racemic epichlorohydrin has been achieved via enantioselective asymmetric ring opening with TMSN3 catalyzed by the (salen) Cr (III) N3 complex 1. The resulting 3-azido-1-chloro-2-trimethylsiloxypropane product was obtained in high enantiomeric purity and incorporated into the synthesis of U-100592, a representative from a class of highly-promising aryl oxazolidinone antibacterial agents.