Synthesis

N-heterocyclic carbene catalyzed hydrophosphonylation of aldehydes

ZH Cai, GF Du, L He, CZ Gu, B Dai

Index: Cai, Zhi-Hua; Du, Guang-Fen; He, Lin; Gu, Cheng-Zhi; Dai, Bin Synthesis, 2011 , # 13 p. 2073 - 2078

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Citation Number: 18

Abstract

In initial experiments, 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (IPr, a stable NHC) [²²] was examined as a catalyst for the coupling reaction of dimethyl trimethylsilyl phosphite and p-chlorobenzaldehyde in tetrahydrofuran (THF; Table [¹] , entry 1). To our delight, the reaction

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