Chemistry Letters

Stereochemistry of amine-catalyzed Knoevenagel reactions

R Tanikaga, N Konya, A Kaji

Index: Tanikaga, Rikuhei; Konya, Naoto; Kaji, Aritsune Chemistry Letters, 1985 , p. 1583 - 1586

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Citation Number: 11

Abstract

The amine-catalyzed Knoevenagel reactions of aldehydes and active methylene compounds containing two activating groups were found to involve many reversible steps, and the diastereomeric intermediary condensation compounds yielded thermodynamically stable products via carbanionic intermediates stabilized and sterically affected by two activating groups.