Organic letters

Asymmetric Bromine–Lithium Exchange: Application toward the Synthesis of Natural Product

J Graff, T Debande, J Praz, L Guénée, A Alexakis

Index: Graff, Julien; Debande, Thibaut; Praz, Jezabel; Guenee, Laure; Alexakis, Alexandre Organic Letters, 2013 ,  vol. 15,  # 16  p. 4270 - 4273

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Citation Number: 6

Abstract

Asymmetric bromine–lithium exchange has been successfully employed to synthesize bicoumarin chiral building blocks of (+)-isokotanin A and (−)-kotanin in good yields and with an excellent level of enantioselectivity. This is the first reported example of formal syntheses, using this direct methodology, leading to the single (M)-atropoisomer of (+)-isokotanin A and (−)-kotanin building blocks, without any resolution step.