Conversion of aryl methyl ketimines to 2, 5-diarylpyrroles using TiCl4/Et3N

M Periasamy, G Srinivas, P Bharathi

Index: Periasamy, Mariappan; Srinivas, Gadthula; Bharathi, Pandi Journal of Organic Chemistry, 1999 ,  vol. 64,  # 11  p. 4204 - 4205

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Citation Number: 106

Abstract

The 2, 5-diarylpyrroles are generally synthesized by following the classical PaalrKnorr synthesis involving the reaction of 1, 4-diketone with amines. 1 Some of the shortcomings in this reaction were overcome by a later method reported by McEwen. 2 Other methods available for pyrrole synthesis are Hantzsch synthesis using chloroacetone and 3-amino ethyl crotonate, 3 1, 3-dipolar cycloaddition reactions involving azalactones, oxazolones, ...