The use of the β-amino-alcohol-n-oxide derivatives in the synthesis of 2, 3 or 4-alkyl substituted nh pyrrolidines

G Roussi, J Zhang

Index: Roussi, Georges; Zhang, Jidong Tetrahedron, 1991 , vol. 47, # 28 p. 5161 - 5172

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Citation Number: 18

Abstract

Nonstabilized azomethine ylides generated from the various β-amino alcohols N-oxides 13, 17, 23 and 24 undergo [3+ 2] cycloaddition reactions with unactivated alkenes to afford the corresponding pyrrolidines 14a-g, 18a-g, 25 and 27 in moderate to good yields. These compounds are precursors of NH pyrrolidines substituted in position 2, 3 or 4.