Synthesis and cytostatic activity of N-[2-(phosphonomethoxy) alkyl] derivatives of N 6-substituted adenines, 2, 6-diaminopurines and related compounds

…, E Tloušťová, M Masojídková

Index: Holy, Antonin; Votruba, Ivan; Tloustova, Eva; Masojidkova, Milena Collection of Czechoslovak Chemical Communications, 2001 , vol. 66, # 10 p. 1545 - 1592

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Citation Number: 65

Abstract

Abstract N 6-Substituted adenine and 2, 6-diaminopurine derivatives of 9-[2- (phosphonomethoxy)-ethyl](PME), 9-[(R)-2-(phosphonomethoxy) propyl][(R)-PMP] and enantiomeric (S)-PMP series were synthesized by reactions of primary or secondary amines with 6-chloro-9-{[2-(diisopropoxyphosphoryl) methoxy] alkyl} purines (26-28) or 2-amino-6- chloro-9-{[2-(diisopropoxy-phosphoryl) methoxy] alkyl} purines (29-31) followed by ...