Functionalized Phosphanyl??Phosphonic Acids as Unusual Complexing Units as Analogues of Fosmidomycin

S Montel, C Midrier, JN Volle, R Braun…

Index: Montel, Sonia; Midrier, Camille; Volle, Jean-Noel; Braun, Ralf; Haaf, Klaus; Willms, Lothar; Pirat, Jean-Luc; Virieux, David European Journal of Organic Chemistry, 2012 , # 17 p. 3237 - 3248

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Citation Number: 10

Abstract

Abstract Fosmidomycin (1a) and FR-90098 are potent inhibitors of 1-deoxy-D-xylulose-5- phosphate reductoisomerase (DXR), the second enzyme of the non-mevalonate (MEP) pathway responsible for the biosynthesis of isoprenoids. This paper describes the synthesis of four types of targets bearing a phosphanyl-phosphonic acid motif as the common core for the inhibition of DXR. In these structures, the hydroxamic acid was replaced by various ...