Bioorganic & medicinal chemistry letters

S-(2-(Acylamino) phenyl) 2, 2-dimethylpropanethioates as CETP inhibitors

K Maeda, H Okamoto, H Shinkai

Index: Maeda, Kimiya; Okamoto, Hiroshi; Shinkai, Hisashi Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 10 p. 2589 - 2591

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Citation Number: 19

Abstract

Studies on the relationship between the structure of the benzene moiety of S-(2-(acylamino) phenyl) 2, 2-dimethylpropanethioates and CETP inhibitory activity were performed. Substituents on the benzene moiety influenced CETP inhibitory activity in a type and position dependent manner, and electron-withdrawing groups at the 4-or 5-position increased the activity. The most potent compound showed 50% inhibition of CETP activity ...