Synthesis of novel dimeric cationic lipids based on an aromatic backbone between the hydrocarbon chains and headgroup
B Paul, A Bajaj, SS Indi, S Bhattacharya
Index: Paul, Bishwajit; Bajaj, Avinash; Indi; Bhattacharya, Santanu Tetrahedron Letters, 2006 , vol. 47, # 47 p. 8401 - 8405
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Citation Number: 12
Abstract
Seven dimeric cationic lipids possessing an aromatic anchor between the hydrocarbon chains and cationic headgroup have been synthesized. The spacers in these lipids vary in length, hydrophobicity and flexibility. The synthesis, membrane-forming properties and complexation with plasmid DNA (lipoplex formation) are briefly described.
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