Synthesis of novel building blocks of 1H-pyrrolo [3, 4-b] quinolin-3 (2H)-one and evaluation of their antitumor activity

L Nagarapua, HK Gaikwad, SR Manikonda…

Index: Nagarapua, Lingaiah; Gaikwad, Hanmant K.; Manikonda, Sheeba Rani; Bantu, Rajashaker; Manda, Krishna Madhuri; Kalivendi, Shasi Vardhan Medicinal Chemistry Research, 2013 , vol. 22, # 1 p. 165 - 174

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Citation Number: 4

Abstract

Abstract A series of new building blocks consisting of 1 H-pyrrolo [3, 4-b] quinolin-3 (2 H)- one with potential as selective antitumor agents is described. Compounds were synthesized by using Heck reaction of N-allyl-1 H-pyrrolo [3, 4-b] quinolin-3 (2 H)-one with p- bromophenyl acetic acid followed by formation of amide (1a–h, 2a–d) by reaction with several secondary amines in good yields. The cytotoxicity of these compounds was ...