Effective silylation of carboxylic acids under solvent-free conditions with tert-butyldimethylsilyl chloride (TBDMSCL) and triisopropylsilyl chloride (TIPSCL)

H Firouzabadi, N Iranpoor…

Index: Firouzabadi, Habib; Iranpoor, Naser; Shaterian, Hamid Reza Phosphorus, Sulfur and Silicon and Related Elements, 2000 , vol. 166, p. 71 - 81

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Abstract

Abstract Various types of carboxylic acids can be converted effectively to their corresponding TBDMS and TIPS esters using TBDMSCI and TIPSCI in the presence of imidazole under solvent-free conditions. The advantage of this modified method in comparison with that reported by Corey is the elimination of DMF, which eliminates aqueous work-up. The method is not a time-consuming process and the reactions proceed spontaneously. By ...

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