Medicinal Chemistry Research

Synthesis and physiological evaluation of new N-nitroso-2, 6-dicarbethoxy-3, 5-diaryltetrahydro-1, 4-thiazine-1, 1-dioxides

N Edayadulla, P Ramesh

Index: Edayadulla, Naushad; Ramesh, Penugonda Medicinal Chemistry Research, 2012 , vol. 21, # 8 p. 2056 - 2063

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Citation Number: 8

Abstract

Abstract A series of new N-nitroso-2, 6-dicarbethoxy-3, 5-diaryltetrahydro-1, 4-thiazine-1, 1- dioxides 4a–r were synthesized and evaluated for antibacterial and antifungal activity. Most of them registered significant antibacterial and antifungal activity. The newly synthesized compounds have been characterized on the basis of elemental analysis, infrared, and nuclear magnetic resonance spectroscopic data.