Tetrahedron Letters

A practical, efficient, and rapid method for the oxidation of electron deficient pyridines using trifluoroacetic anhydride and hydrogen peroxide–urea complex

S Caron, NM Do, JE Sieser

Index: Caron, Stephane; Do, Nga M.; Sieser, Janice E. Tetrahedron Letters, 2000 , vol. 41, # 14 p. 2299 - 2302

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Citation Number: 78

Abstract

A general method for the oxidation of electron-poor pyridines to their N-oxides using UHP and TFAA in either CH2Cl2 or CH3CN was developed. The methodology proved to tolerate a number of functional groups and substitution patterns and proceeded on notoriously difficult to oxidize substrates.