Synthesis and anti-leukaemic activity of pyrrolo [3, 2, 1-hi] indole-1, 2-diones, pyrrolo [3, 2, 1-ij] quinoline-1, 2-diones and other polycyclic isatin derivatives

L Matesic, JM Locke, KL Vine, M Ranson, JB Bremner…

Index: Matesic, Lidia; Locke, Julie M.; Vine, Kara L.; Ranson, Marie; Bremner, John B.; Skropeta, Danielle Tetrahedron, 2012 , vol. 68, # 34 p. 6810 - 6819

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Citation Number: 17

Abstract

To further expand the structure–cytotoxic activity relationships of isatin derivatives and to reduce flexibility in substituent groups at nitrogen, 20 analogues incorporating a ring system between the N1 and C7 atoms of isatin were prepared using a variety of synthetic strategies. This yielded pyrroloindole-, pyrroloquinoline-, pyrroloacridine-, pyrrolophenanthridine-and benzopyrrolophenanthridine-based systems with embedded isatin moieties, the latter ...