Microwave??Assisted [3+ 2] Cycloaddition and Suzuki–Miyaura Cross??Coupling for a Concise Access to Polyaromatic Scaffolds

D Hedou, E Deau, C Dubouilh??Benard…

Index: Hedou, Damien; Deau, Emmanuel; Dubouilh-Benard, Carole; Sanselme, Morgane; Martinet, Anthony; Chosson, Elizabeth; Levacher, Vincent; Besson, Thierry European Journal of Organic Chemistry, 2013 , # 33 p. 7533 - 7545

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Citation Number: 4

Abstract

Abstract Novel 3-(prop-2-ynyl) pyrido [2, 3-d] pyrimidin-4 (3H)-ones and 3-(prop-2-ynyl) quinazolin-4 (3H)-ones have been synthesized in a high-yielding microwave-assisted one- pot procedure. The one-pot sequence was conveniently extended to the synthesis of commercially unavailable 6-bromo-N 3-propargylpyrido [2, 3-d] pyrimidinone by a regiocontrolled bromination with NBS. The synthetic scaffolds were successfully converted ...

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