A novel Lewis acid-promoted enyne cycloisomerization of triester-substituted alkenesElectronic supplementary information (ESI) available: experimental procedures …

S Yamazaki, K Yamada, T Otsubo, M Haruna…

Index: Yamazaki; Yamada; Otsubo; Haruna; Kutsuwa; Tamura Chemical Communications, 2001 , # 1 p. 69 - 70

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Abstract

The design of a Lewis acid-promoted enyne cyclization requires that a highly electrophilic alkene (or alkyne) has coordination sites for a Lewis acid and that the other component (alkyne or alkene) works as a nucleophile. Alkenes with three ester groups are considered to be highly electrophilic and very reactive towards nucleophilic olefins, 5 and they may react intramolecularly with alkynes which are relatively unreactive nucleophiles. 6 ‡ We thus examined Lewis ...