Tetrahedron Letters

Copper-free Sonogashira cross-coupling reaction catalyzed by polymer-supported N-heterocyclic carbene palladium complex

JH Kim, DH Lee, BH Jun, YS Lee

Index: Kim, Jong-Ho; Lee, Dong-Ho; Jun, Bong-Hyun; Lee, Yoon-Sik Tetrahedron Letters, 2007 , vol. 48, # 40 p. 7079 - 7084

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Citation Number: 89

Abstract

A core-shell type of polymer-supported N-heterocyclic carbene (NHC) palladium catalyst was applied to Sonogashira cross-coupling reactions without copper cocatalyst under ambient atmosphere. This supported NHC–palladium complex efficiently catalyzed the copper-free Sonogashira reaction of various aryl iodides and bromides with terminal alkynes; the reaction exhibited high dependency on the temperature and the amount of ...

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