Unsymmetrical Diacyl Derivatives of 4, 4'-Diaminodiphenyl Sulfone

HA Shonle, AM VanArendonk

Index: Shonle; Van Arendonk Journal of the American Chemical Society, 1943 , vol. 65, p. 2375

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Citation Number: 2

Abstract

In the search for new chemotherapeutic agents, it was early observed that 4, 4'- diaminodiphenyl sulfone was more effective, on a weight basis, than sulfanilamide in combatting streptococcic and certain other infections in white mice. Bauer and Rosenthal'reported a therapeutic index of 6 for 4, 4'-diaminodiphenylsulfone and a therapeutic index of 3.3 for sulfanilamide in white mice infected with hemolytic ...