Antiprotozoal quinones. II. Synthesis of 4-amino-1, 2-naphthoquinones and related compounds as potential antimalarials

FJ Bullock, JF Tweedie, DD McRitchie…

Index: Bullock; Tweedie; McRitchie; Tucker Journal of medicinal chemistry, 1970 , vol. 13, # 1 p. 97 - 103

Full Text: HTML

Citation Number: 26

Abstract

A wide variety of 4-amino-1, 2-naphthoquinones, related to the presumed active metabolite of pamaquine, has been prepared and evaluated as potential antimalarials in Plnsmodirtm berghei infected mice, Plasmodium gallinaceurn infected chicks, and against the sexual phase of P. gallinaceurn in mosquitoes.-4 few new" amino-1, 4-naphthoquinones and 4- alkoxy-1, 2-naphthoquinones have also been prepared and evaluated. Sone of the new ...