Synthesis of pyrrolostatin and its analogues

Y Fumoto, T Eguchi, H Uno, N Ono

Index: Fumoto, Yumiko; Eguchi, Tomomi; Uno, Hidemitsu; Ono, Noboru Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6518 - 6521

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Citation Number: 32

Abstract

Pyrroles are not only important building blocks in nature such as in hemes, chlorophyll, and various porphyrinoids, 1 but also commonly found as various kinds of derivatives in living cells to show biological activity. 2 Thus, there have been many synthetic studies on pyrrole derivatives. In 1993, Kato et al. isolated a novel lipid peroxidation inhibitor, pyrrolostatin (1a), from Streptomyces chrestomyceticus, which consists of a pyrrole-2-carboxylic acid with a ...

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