New Highlights in the Synthesis of 4??Aryl??1, 4??dihydropyrazines

…, XQ Song, H Yan, RG Zhong

Index: He, Jing-Yu; Song, Xiu-Qing; Yan, Hong; Zhong, Ru-Gang Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 6 p. 1357 - 1361

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Citation Number: 5

Abstract

Abstract The 4-aryl-1, 4-dihydropyrazines were prepared via the cyclization of N, N- bisalkylated anilines with ammonium acetate. These reactions were aided by improvements in the synthesis of N, N-bisalkylated anilines which were alkylated with anilines using ethyl 2- diazo acetoacetate in a reaction catalyzed by rhodium acetate in the absence of oxygen. A possible mechanistic route is postulated on the basis of the isolation of the N-alkylation ...