Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors

Z Zhang, C Liu, X Li, T Song, Z Wu, X Liang…

Index: European Journal of Medicinal Chemistry, , vol. 60, p. 410 - 420

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Citation Number: 14

Abstract

... European Journal of Medicinal Chemistry. Volume 60, February 2013, Pages 410–420. Cover image Cover image. Original article. ... Compounds 6e–j were obtained by reaction of the corresponding thiophenol with 1 in the presence of cesium carbonate. ...

Design and synthesis of 1, 4, 5, 6-tetrahydropyrrolo [3, 4-c] pyrazoles and pyrazolo [3, 4-b] pyridines for Aurora-A kinase inhibitors

[Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 14 p. 4273 - 4278]

Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors

Abstract

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