Phosphine-directed stereo-& regioselective Ni-catalyzed reactions of Grignard reagents with allylic ethers

MT Didiuk, JP Morken, AH Hoveyda

Index: Didiuk, Mary T.; Morken, James P.; Hoveyda, Amir H. Tetrahedron, 1998 , vol. 54, # 7 p. 1117 - 1130

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Citation Number: 31

Abstract

Studies on the directed regio-and stereoselective Ni-catalyzed allylic substitution reactions involving methyl-and phenylmagnesium bromides and various acyclic and cyclic allylic ethers are reported. In the presence of a properly positioned internal Lewis base, C C bonds can be formed catalytically and with excellent levels of selectivity. Internal chelation allows Ni-catalyzed C C bond forming reactions that are otherwise non-selective, ...