Photochemical synthesis of novel dideoxynucleosides

E Lee-Ruff, R Margau

Index: Lee-Ruff; Margau Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 3 p. 185 - 196

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Citation Number: 13

Abstract

A series of 2′, 3′-dideoxynucleosides based on the apiose family was prepared from photochemical ring-expansion of a common cyclobutanone precursor. The starting ketone,(±) 3-[2′-(benzoyloxy) ethyl]-2, 2-dimethylcyclobutanone (12) was prepared from commercially available (±) α-pinene. Since the optically pure antipodes of α-pinene are also commercially available, these nucleosides can be prepared optically pure using the ...