Synthese de l'acide (chloro??3 cyclohexyl??4 phenyl)??4 oxo??4 butyrique (804 CB) marque au carbone 14

L Pichat, JP Beaucourt, M Herbert…

Index: Pichat; Beaucourt; Herbert; et al. Journal of Labelled Compounds and Radiopharmaceuticals, 1976 , vol. 12, # 4 p. 483 - 489

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Abstract

Abstract The Grignard reagent made from p-cyclohexyl m-chloroiodobenzene is carbonated with 14 CO 2 to give 3-chloro 4-cyclohexyl benzoǐc acid (radioactive yield 50%). This acid is transformed into the corresponding chloride with thionyl chloride. Condensation of the chloride with tris-(trimethylsilyl) 1-lithio-1, 1, 2 ethane tricarboxylate gives after hydrolysis 4- (3-chloro 4-cyclohexyl phenyl) 4-oxobutyric acid 4-14 C with an overall yield of 41% ...