Synthesis of 3??alkylcarbonyloxymethyl derivatives of 5??fluorouracil
WJ Roberts, KB Sloan
Index: Roberts, William J.; Sloan, Kenneth B. Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 5 p. 905 - 910
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Citation Number: 10
Abstract
Abstract 3-Alkylcarbonyloxymethyl derivatives of 5-fluorouracil have been synthesized starting with 1-ethyloxy-carbonyl-5-fluorouracil. Alkylation of the starting material with alkylcarbonyloxymethyl iodides, generated from the corresponding chlorides by the Finkelstein reaction, in the presence of 1, 8-bis (dimethyl-amino) naphthalene followed by deprotection with 1, 1-dimethylethylamine gave good yields (50-60%) of the target ...
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