Tetrahedron Letters

Alkenyl bromides: useful coupling partners for the palladium-catalysed coupling with heteroaromatics via a C–H bond activation

AL Gottumukkala, F Derridj, S Djebbar, H Doucet

Index: Gottumukkala, Aditya L.; Derridj, Fazia; Djebbar, Safia; Doucet, Henri Tetrahedron Letters, 2008 , vol. 49, # 18 p. 2926 - 2930

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Citation Number: 52

Abstract

Alkenyl bromides were found to be useful reactants for the palladium-catalysed direct C–H activation/functionalisation reaction of heteroaromatics such as benzoxazole or benzothiazole. Moderate to good yields of coupling products were obtained using both α- and β-substituted alkenyl bromides or even the trisubstituted alkenyl bromide 2-bromo-3- methylbut-2-ene. This reaction is environmentally attractive as it provides only HX ...