Tetrahedron Letters

Selective direct arylation of 3-bromo-2-methylthiophene: a building-block for electro-and photoactive organic materials

G Vamvounis, D Gendron

Index: Vamvounis, George; Gendron, David Tetrahedron Letters, 2013 , vol. 54, # 29 p. 3785 - 3787

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Citation Number: 7

Abstract

Selective direct arylation of 3-bromo-2-methylthiophene with aryl bromides to form a library of 2-aryl-4-bromo-5-methylthiophenes is demonstrated. The reaction yields varied from 27– 63%. The inherent selectivity observed is attributed to the lack of oxidative insertion of the bromine in 3-bromo-2-methylthiophene. This method will be useful for the facile preparation of functional organic electronic materials.

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