The Journal of Organic Chemistry

Synthesis of diamagnetic structural analogs of representative doxyl, proxyl, piperidine, and pyrroline nitroxide spin labels

JFW Keana, SE Seyedrezai

Index: Keana, John F. W.; Seyedrezai, Seyed E. Journal of Organic Chemistry, 1982 , vol. 47, # 2 p. 347 - 352

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Citation Number: 9

Abstract

The objective of this work is the synthesis of diamagnetic close structural analogues of the more important doxyl 4, proxy1 5, piperidine 6, and pyrrolidine 7 nitroxide spin labels which are extensively used in biophysical investigations. Our approach is based on the observation that a nitroxide group is similar both in size and polarity to a carbonyl group of a ketone. Diamagnetic doxyl nitroxide analogues 11, 12, and 13 were prepared by a series ...