(2-Aryl-5-methylimidazol-4-ylcarbonyl) guanidines and (2-aryl-5-methyloxazol-4-ylcarbonyl) guanidines as NHE-1 inhibitors

S Lee, KY Yi, SJ Youn, BH Lee, S Yoo

Index: Lee, Sunkyung; Yi, Kyu Yang; Youn, Sung Jun; Lee, Byung Ho; Yoo, Sung-eun Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1329 - 1331

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Citation Number: 13

Abstract

A series of (2-aryl-5-methylimidazol-4-ylcarbonyl) guanidines and (2-aryl-5-methyloxazol-4- ylcarbonyl) guanidines were synthesized and evaluated as NHE-1 inhibitors. The structure– activity relationships well matched those of furan derivatives, which were previously investigated. The (2, 5-disubstituted) phenyl compounds showed better activities than the other analogues in both imidazole and oxazole compounds. Especially, 2-(2, 5- ...