[18 F] Fluoromethyl iodide ([18 F] FCH 2 I): preparation and reactions with phenol, thiophenol, amide and amine functional groups

…, M Ogawa, K Furutsuka, Y Yoshida, K Suzuki

Index: Zhang, Ming-Rong; Ogawa, Masanao; Furutsuka, Kenji; Yoshida, Yuichiro; Suzuki, Kazutoshi Journal of Fluorine Chemistry, 2004 , vol. 125, # 12 p. 1879 - 1886

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Citation Number: 15

Abstract

In this study, we report the synthesis and reactivity of [18F] fluoromethyl iodide ([18F] FCH2I) with various nucleophilic substrates and the stabilities of [18F] fluoromethylated compounds.[18F] FCH2I was prepared by reacting diiodomethane (CH2I2) with [18F] KF, and purified by distillation in radiochemical yields of 14–31%(n= 25).[18F] FCH2I was stable in organic solvents commonly used for labeling and aqueous solution with pH 1–7, but ...