Discovery of molecules for the treatment of neuropathic pain: Synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl) furoic-2-acid hydrazones

P Yogeeswari, N Menon, A Semwal, M Arjun…

Index: Yogeeswari, Perumal; Menon, Niloufer; Semwal, Arvind; Arjun, Muralidharan; Sriram, Dharmarajan European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 2964 - 2970

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Citation Number: 13

Abstract

Abstract Neuropathic pain is a chronic pain condition that occurs and persists in a heterogeneous group of etiologically different diseases characterized by a primary lesion or dysfunction of the peripheral or central nervous system. Current treatment options do not provide adequate relief for many patients and a significant number of the agents used have dose limiting side effects. During the course of our work on the synthesis and screening of ...