Synthesis and pharmacological activity of N-(2, 2-dimethyl-3, 4-dihydro-2H-1-benzopyran-4-yl)-4H-1, 2, 4-benzothiadiazine-3-carboxamides 1, 1-dioxides on rat …

…, M Yekhlef, P De Tullio, P Lebrun, B Pirotte

Index: Khelili, Smail; Kihal, Nadjib; Yekhlef, Mohamed; De Tullio, Pascal; Lebrun, Philippe; Pirotte, Bernard European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 873 - 878

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Citation Number: 12

Abstract

N-(2, 2-Dimethyl-3, 4-dihydro-2H-1-benzopyran-4-yl)-4H-1, 2, 4-benzothiadiazine-3- carboxamides 1, 1-dioxides were prepared and evaluated on rat uterus, rat aortic rings and rat pancreatic β-cells. Pharmacological studies conducted on rat uterus indicated that several of these original hybrid compounds displayed a strong myorelaxant activity. The most active compounds hold a bromine atom at the 6-position of the dihydrobenzopyran ...