Nonsteroidal antiinflammatory agents. 2.[(Heteroarylamino) phenyl] alkanoic acids

K Hino, H Nakamura, Y Nagai, H Uno…

Index: Hino; Nakamura; Nagai; Uno; Nishimura Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 222 - 226

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Citation Number: 14

Abstract

A series of [(heteroarylamino) phenyl] alkanoic acids having pyridine, quinoline, or pyrimidine as the heteroaryl moiety was prepared as potential antiinflammatory agents. Among them, 2-[4-(2-pyridylamino) phenyl] propionic acid (14b) showed excellent antiinflammatory and analgesic activities with less tendency to cause gastric side effects. Structure-activity relationships are discussed.