The Journal of organic chemistry

Total synthesis of Amaryllidaceae alkaloids utilizing sequential intramolecular heterocyclic azadiene Diels-Alder reactions of an unsymmetrical 1, 2, 4, 5-tetrazine

DL Boger, SE Wolkenberg

Index: Zwierzak, Andrzej; Osowska, Krystyna Synthesis, 1984 , # 3 p. 223 - 224

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Citation Number: 73

Abstract

... Total Synthesis of Anhydrolycorinone, Anhydrolycorinium Chloride, and Hippadine. 2-Bromopiperonal was protected as its diethyl ketal [HC(OEt) 3 , p-TsOH, EtOH, 80 °C, 24 h] and converted to the known aldehyde 7 11 via lithium−halogen exchange (n-BuLi, Et 2 O, −30 °C, ...