Polymer conjugates of the highly potent cytostatic drug 2-pyrrolinodoxorubicin

M Studenovsky, K Ulbrich, M Ibrahimova…

Index: Studenovsky; Ulbrich; Ibrahimova; Rihova European Journal of Pharmaceutical Sciences, 2011 , vol. 42, # 1-2 p. 156 - 163

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Citation Number: 5

Abstract

This paper describes the synthesis and biological evaluation of a conjugate of the highly cytotoxic drug 2-pyrrolinodoxorubicin (p-DOX) with an N-(2-hydroxypropyl) methacrylamide copolymer (PHPMA) as a water-soluble biocompatible polymer carrier, utilizing the advantageous concept of polymer–drug conjugates. The conjugate of p-DOX with HPMA copolymer (PHPMA/p-DOX) was prepared by reacting the PHPMA/DOX conjugate, where ...