Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl) methylene) imidazolidine-2, 4-diones and 5-((N-benzyl-1H-indol-3-yl) methylene) pyrimidine-2, 4, 6 (1H, 3H, 5H)- …

…, KR Sekhar, N Sasi, PN Reddy, ML Freeman…

Index: Reddy, Y. Thirupathi; Sekhar, Konjeti R.; Sasi, Nidhish; Reddy, P. Narsimha; Freeman, Michael L.; Crooks, Peter A. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 600 - 602

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Citation Number: 34

Abstract

A series of (Z)-5-((N-benzyl-1H-indol-3-yl) methylene) imidazolidine-2, 4-dione (9a–9m) and 5-((N-benzyl-1H-indol-3-yl) methylene) pyrimidine-2, 4, 6 (1H, 3H, 5H)-trione (10a–10i) derivatives that incorporate a variety of aromatic substituents in both the indole and N-benzyl moieties have been synthesized. These analogs were evaluated for their radiosensitization activity against the HT-29 cell line. Three analogs, 10a, 10b, and 10c were identified as ...