Convenient synthesis and isolation of trifluoromethylthio-substituted building blocks
A Harsányi, É Dorkó, Á Csapó, T Bakó, C Peltz…
Index: Harsanyi, Antal; Dorko, Eva; Csapo, Agnes; Bako, Tibor; Peltz, Csaba; Rabai, Jozsef Journal of Fluorine Chemistry, 2011 , vol. 132, # 12 p. 1241 - 1246
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Citation Number: 21
Abstract
Various aryl-, heteroaryl-, and alkyl mercaptanes (RSH, 1a–r) were treated with a slight excess of NaH suspended in DMF to make the appropriate sodium thiolates (RSNa), which then reacted with 1.3 equivalent of CF3I at room temperature for overnight to afford the appropriate trifluoromethyl sulfides (CF3SR, 2) in fair to good yields. The radical chain alkylation reaction was effective without the use of UV irradiation with all but three ...
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