Tyrosine??like condensed derivatives as tyrosinase inhibitors
MJ Matos, L Santana, E Uriarte, S Serra…
Index: Matos, Maria Joao; Santana, Lourdes; Uriarte, Eugenio; Serra, Silvia; Corda, Marcella; Fadda, Maria Benedetta; Era, Benedetta; Fais, Antonella Journal of Pharmacy and Pharmacology, 2012 , vol. 64, # 5 p. 742 - 746
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Citation Number: 12
Abstract
Objectives We report the pharmacological evaluation of a new series of 3-aminocoumarins differently substituted with hydroxyl groups, which have been synthesized because they include in their structures the tyrosine fragment (tyrosine-like compounds), with the aim of discovering structural features necessary for tyrosinase inhibitory activity. Methods The synthesized compounds 4 and 7–9 were evaluated in vitro as mushroom tyrosinase ...
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