Molecules

Bortezomib congeners induce apoptosis of hepatocellular carcinoma via CIP2A inhibition

…, AC Huang, CW Shiau, CY Wang, HC Yu, KF Chen

Index: Hou, Duen-Ren; Huang, Ann-Chi; Shiau, Chung-Wai; Wang, Chun-Yi; Yu, Hui-Chuan; Chen, Kuen-Feng Molecules, 2013 , vol. 18, # 12 p. 15398 - 15411

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Citation Number: 3

Abstract

Abstract: CIP2A is an oncoprotein that upregulates p-Akt and promotes cancer cell proliferation and survival. The proteasome inhibitor bortezomib has been shown to reduce CIP2A and lead to cell apoptosis. Here; we modified the functional group of bortezomib to generate a series of novel compounds and conducted a structure–activity relationship (SAR) study. The results showed that compound 1 was able to repress CIP2A expression and ...