Ro 11–2933, a potential drug in the treatment of cancer and malaria: synthesis and physicochemical properties; potential metabolites
H Ramuz, W Schmutz, R Huber
Index: Ramuz; Schmutz; Huber European Journal of Medicinal Chemistry, 1989 , vol. 24, # 5 p. 493 - 496
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Citation Number: 7
Abstract
Abstract Ro 11–2933, 4b, a compound with minor cardiovascular activity has been shown to reverse multidrug resistance in cancer cells as well as chloroquine resistance in Plasmodium falciparum. A useful synthesis of the drug is described. Alkylation of dithiane (2) with chloroalkylamine (3) affords 4b as a crystalline compound in a very good yield. The synthesis of its potential metabolites 7 and 11 has also been carried out.
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