Crystalline diethylstilbestrol (DES) quinone: synthesis, x-ray analysis, and stability

YJ Abul-Hajj, K Tabakovic, WH Ojala…

Index: Abul-Hajj, Yusuf J.; Tabakovic, Katmerka; Ojala, William H.; Gleason, William B. Journal of the American Chemical Society, 1995 , vol. 117, # 20 p. 5600 - 5601

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Citation Number: 7

Abstract

Diethylstilbestrol (DES) is a synthetic estrogen that has been shown to be carcinogenic in humans and animals.'While the exact mechanisms underlying DES carcinogenicity are not fully understood, it has been proposed that the oxidation of DES to the corresponding DES quinone by either peroxidase2q3 or cytochrome P-450" may be responsible for its carcinogenic a~ tivity.~-~ The existence of DES quinone (DES Q) has been inferred from ...