A simple and regioselective conversion of terminal acetylene into 2-substituted acrylonitrile
FT Luo, SL Ko, DY Chao
Index: Luo, Fen-Tair; Ko, Sheng-Li; Chao, Dean-Yang Tetrahedron Letters, 1997 , vol. 38, # 46 p. 8061 - 8062
Full Text: HTML
Citation Number: 5
Abstract
The addition of hydrogen cyanide to alkynes catalyzed by transition metal complexes to form α,β-unsaturated nitriles are potentially useful in organic synthesis.1, 2 and 3Although hydrogen cyanide can be generated in situ from acetone cyanohydrin to avoid the use of the poisinous hydrogen cyanide, [4]one or two moles of hydrogen cyanide may add to a triple bond, since the initial product is a Michael-type substrate which may easily undergo the second addition ...
Related Articles:
[Basavaiah, Deevi; Kumaragurubaran, Nagaswamy Tetrahedron Letters, 2001 , vol. 42, # 3 p. 477 - 479]
A new simple synthesis of α-substituted acrylonitriles
[Baraldi, P. G.; Pollini, G. P.; Zanirato, V.; Barco, A.; Benetti, S. Synthesis, 1985 , # 10 p. 969 - 970]
A General Synthesis of α-Substituted Acrylonitriles
[Miller,R.B.; Smith,B.F. Synthetic Communications, 1973 , vol. 3, p. 413 - 417]
A General Synthesis of α-Substituted Acrylonitriles
[Miller,R.B.; Smith,B.F. Synthetic Communications, 1973 , vol. 3, p. 413 - 417]
A General Synthesis of α-Substituted Acrylonitriles
[Miller,R.B.; Smith,B.F. Synthetic Communications, 1973 , vol. 3, p. 413 - 417]