Tetrahedron Letters

The synthesis of erhthro-and threo-N-methyl 7-Hydroxy-1, 2, 9, 10-tetramethoxyaporphine

S Chackalamannil, DR Dalton

Index: Chackalamannil, Samuel; Dalton, D. R. Tetrahedron Letters, 1980 , vol. 21, p. 2029 - 2032

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Citation Number: 5

Abstract

Pachorr cyclization of 5 in a mixture of glacial acetic and concentrated sulfuric acids (6: 1, v/v) using sodium nitrite, followed by dilution with acetone and addition of EDTA-activated, freshly prepared, Gatterman copper provided the bright ye&w oxoaporphine 0 in 20-25s yield along with numerous other products.