Synthesis and antihepatotoxic activity of 5-(2, 3-dihydro-1, 4-benzodioxane-6-yl)-3-substituted-phenyl-4, 5-dihydro-1H-pyrazole derivatives

H Khalilullah, S Khan, MJ Ahsan, B Ahmed

Index: Khalilullah, Habibullah; Khan, Shamshir; Ahsan, Mohamed Jawed; Ahmed, Bahar Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7251 - 7254

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Citation Number: 23

Abstract

In continuance of our search for newer antihepatotoxic agents some novel pyrazoline derivatives containing 1, 4-dioxane ring system were synthesized starting from 3-(2, 3- dihydro-1, 4-benzodioxane-6-yl)-1-substituted-phenylprop-2-en-1-one. Some of the synthesized compounds were evaluated for antihepatotoxic activity against CCl4-induced hepatotoxicity in rats. Among them some compounds have shown significant ...